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Diabetes mellitus (DM), considered by hyperglycemia and carbohydrate, protein and fat metabolism disturbances, is an extensive metabolic disease. It's influence the patient personal satisfaction as far as social, psychological prosperity and physical sick wellbeing (Dewanjee et al., 2009). DM is a chronic  metabolic disorder manifested with elevated levels of glucose in the body, which is an impact of debilitated insulin emission, insulin impact, or both. DM is a common scenario in the South and East Asia region mostly in Bangladesh, India, Sri Lanka, Bhutan, Mauritius, and Maldives (Nanditha et al., 2016). According to the latest reports, more than 382 million people are affected with diabetes in 2013 and estimated to reach a total of 592 million by 2035 (International Diabetes Federation, 2013). DM is classified by Two forms. One is Types 1 (T1DM) and another one is Type 2 (T2DM), it is differ in their pathogenesis, but both have hyperglycaemia as a common trademark. T1DM body fails to produce insulin, whereas in T2DM shows resistance to insulin. T2DM is a contribution of many alteration genes and their products.

Identification of potent Cyanoacetylhydrazone derivatives as antidiabetic activity by in silico method