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Now a days many dosage forms are available; topical preparation is one of them. It avoids the GI-irritation and firstpass effect and increase the drug bioavailability (Jani et al., 2010).Gels are defined as a semi solid system consisting of two phases and produce cross linked three dimensional rigid networks like structure. The structural materials that form the gel network can be composed of inorganic or organic particles and polymers where the inorganic particles are not dissolve but merely dispersed throughout the continuous phase and organic particles are dissolved in continuous phase, randomly coiled in the flexible chain (Kaur et al., 2013).

Development and evaluation of Metronidazole containing topical gel using different gelling agents