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The effect of adrenelectomy was studied on the antioxidant metabolism in different tissues (Liver, heart, kidney and muscle) of rat. G-6-PDH was increased significantly in liver and heart and the same was decreased in kidney with a non significant change in muscle. SOD was significantly increased in heart and muscle. Catalase was significantly decreased in liver and muscle and was increased significantly in kidney. XOD showed significant decrease in liver and increase in heart, kidney and muscle. The present finding, in general, exhibit tissue specificalterations in free radical metabolism in conjunction with antioxidant defence mechanisms during adrenal hormone deficiency. It is also clear from the results that the mechanisms involved in selective activation / inhibition of different pathways seems to reflect multifaceted physiological adaptations as a compensatory measure during induced adrenalectomy.

Adrenal hormone insufficiency impact on antioxidant metabolism in the tissues of rat