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Bacterial cellulose  (BC)  is an advantageous wound healing matrix and widely utilized  in dressings thanks to  its  interesting physical properties. Lacking bioactivity, BC has been subject to modifications for  improving  its biological properties.  It has been modified with  silk  sericin  (SS) mainly  for  its  antioxidant  and mitogenic  effects,  yielding  enhanced wound  healing abilities. Besides, patterned BC exhibited anti‐scar behavior, inhibiting the growth of skin fibroblasts. Incorporating surface microgrooves together with SS in BC, the current study proposes dressings that would improve healing, reduce healing time, and  still  achieve  reduced  fibrosis,  by  controlling  collagen  deposition  and  inducing  profitable  microgroove‐oriented architecture.  In  vitro  experiments  demonstrated  an  enhanced  proliferation  of  both  fibroblast  and  epithelial  cells with alignment on  the microstructured  composite  samples  relative  to  the unmodified  controls. Compared  to  the unmodified control where collagen synthesis was rapid and reached the peak value  in a relatively short time, on the microstructured surface a progressive and more contained profile was observed. Thus, the structured composite dressings would accelerate healing due to an  improved cell growth, while preventing the anarchic deposition of collagen responsible for fibrosis and scar formation through cell orientation.

Combining Silk Sericin and Surface Micropatterns in Bacterial Cellulose Dressings to Control Fibrosis and Enhance Wound Healing