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In this study, the changes caused by Flavobacterium psychrophilum inactivated with formalin in some antioxidant enzyme parameters in juvenile rainbow trout were investigated. Rainbow trout juveniles weighing about 1.0 g were treated with 1 x 108 CFU / ml bacterin inactivated with formalin for 30, 60 and 90 minutes. Fish were stimulated with 1 x 108 CFU / ml live F. psychrophilum 21 days after application. Fourteen days later, changes in malondialdehyde (MDA), superoxide dismutase, catalase and reduced glutathione activities were investigated with samples taken from fish. A decrease was observed in MDA level especially in fish treated with bacteria for 60 and 90 minutes compared to positive control group. Likewise, a positive change was found in antioxidant enzyme activities. As a result; It has been determined that the bacterial preparation that is inactivated with formalin can be effective in the regulation of the oxidant / antioxidant balance, which is disturbed by the live F. psychrophilum bacteria.

Formalin ile İnaktive Flavobacterium psychrophilum’un Gökkuşağı Alabalığı (Oncorhynchus mykkiss)’nın Antioksidan Enzimlerine Etkisi