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The article presents a modern view of the endothelium and main functions supporting the physiology of the vascular and homeostasis for the normal functioning of the cardiovascular system. An analysis of studies on the formation of endothelial dysfunction and effect on the formation a pathological cascade of cardiovascular events is carried out. The mechanisms of formation endothelial dysfunction involved in inflammation, progression of atherosclerosis and the possibility of modern diagnosis of vascular remodeling are presented. An analysis of the release of nitric oxide, which influences the formation of endothelial dysfunction in arterial hypertension, is carried out.

Endothelial dysfunction in the pathogenesis of arterial hypertension and the progression of atherosclerosis