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2 Introduction 4 Materials and Methods 7 Animals 7 Surgery 7 Experimental Design 7 Electrochemistry 8 Measurements with Electrical Stimulation 9 Analysis of Dopamine Release and Uptake 9 Analysis of Basal Dopamine Levels and Dopamine Transients 9 Statistical Analysis 10 Drugs 10 Results 12 Modafinil Robustly Increases the Amplitude of Electrically Evoked Phasic-Like Dopamine Signals 12 Modafinil Increases Dopamine Release and Decreases Dopamine Uptake 13 Modafinil Has Negligible Effects on Basal Dopamine Levels 15 Modafinil Activates Dopamine Transients 17 Discussion 18 Modafinil Effects on Basal Dopamine Levels 18

The effects of modafinil and atomoxetine on dopamine signaling in the striatal subregions of the rat