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Background: Determining severity of mitral regurgitation (MR) is very important, as it is related with prognosis and management of the disease. Currently, there is no gold standard exists for quantification of MR severity using echocardiography. American Society of Echocardiography (ASE) guidelines recommend several parameters based on integrative criteria using color and spectral Doppler and anatomic measurement. Left Ventricular Early Inflow Outflow Index (LVEIO Index) was proposed as one parameter to assess the severity of MR by omitting geometric error from regurgitant volume method. Thus, LVEIO index offers a simple, easy and accurate measurement in determining severity of MR. Methods: This study was a diagnostic test research with cross-sectional design. The subjects were all patients with organic mitral regurgitation who underwent echocardiography examination to measure severity of MR using the LVEIO index as well as other parameters measurements based on parameters of ASE guidelines. Diagnostic test was used to determine the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of LVEIO index. Results: Of 49 patients in this study, 23 of them have severe MR and 26 are non-severe MR patients. The proportion of gender between two groups almost similar with an age range from 56 to 61 years and the most common etiology finding was degenerative MR. Echocardiography examination showed the ejection fraction in severe MR was 63±4.2% and 64±3.9% in non-severe MR. The value of LAVI, MPAP, E-wave, VC, EROA and LVEIO index increased parallel with severity of MR (LAVI; 67±18.2 vs. 40±14.2 ml/m2, MPAP; 28±12.8 vs. 20±12.6 mmHg, E-wave 1.5±0.3 vs. 1±0.2 m/s, VC 0.8±0.3 vs. 0.5±0.1 cm, EROA 0.4±0.1 vs 0,2±0,1cm2, LVEIO 9±2,4 vs. 5±1,8). The sensitivity, specificity, and accuracy of LVEIO index for diagnosis of severe MR were 86%, 84%, and 89%, respectively. Conclusion: LVEIO can be proposed as a relatively simple, easy and accurate method in determining severity of MR.

Diagnostic Value of Left Ventricular Early Inflow-Outflow Index in Determining Severity of Mitral Regurgitation