Open AccessA Quick update from the Past to Current Status of Human Pluripotent Stem Cell-derived Hepatocyte culture systems
Author(s) -
Ensieh Zahmatkesh,
Massoud Vosough
Publication year - 2018
Publication title -
modern medical laboratory journal
Language(s) - English
Resource type - Journals
ISSN - 2371-770X
DOI - 10.30699/mmlj17.1.3.110
Subject(s) - induced pluripotent stem cell , human induced pluripotent stem cells , hepatocyte , stem cell , microbiology and biotechnology , cell culture , biology , embryonic stem cell , genetics , in vitro , gene
Drug-screening Pluripotent stem cells (PSCs) may be offered as an unlimited cell source for the hepatocyte generation. The generation of hepatocytes from stem cells in vitro would provide an alternative cell source for applications in drug discovery and cell transplantation. In this review, we discuss different approaches to generate pluripotent stem cell-derived hepatocytes, advantages, limitations for each method and finally, how three-dimensional (3D) strategy can improve the maturation of PSCs -derived hepatocytes.
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