English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Lactobacillus acidophilus, Gram-positive bacterias that enter the dentinal tissue during the carious process are suspected to inuence the immune response in human dental pulp. Odontoblasts situated at the pulp dentin interface are the frst cells encountered by these bacteria and have an important role in this response. Lipoteichoic acid (LTA), a wall component of Gram-positive bacteria, triggered the activation of the odontoblasts. LTA upregulated the expression of its own receptor TLR2, as well as the production of proinammatory cytokineTNFα. Propolis is a resinous material that holds a great potential as an antiinammatory agent. Present studies have shown that propolis has a reduction eect towards the proinammatory cytokines expression and favor pulp healing. Purpose: To reveal the moleculer mechanism of propolis stimulation on odontoblast like cells, induced by inactive Lactobacillus acidophilus. Methods: This review was presented in odontoblasts like cells culture induced by inactive Lactobacillus acidophilus and exposed to propolis extract. Pulp cell culture isolated from human impacted thirds molar that has been extracted. Observation and measurement the expression of TLR2 and TNFα was processed by using immunocytochemistry (ICC) technic. Result: Data analysis with ANOVA test, a signifcant dierence in every group (p<0,05) was present. The expression of TLR2 and TNFα were shown at low level percentation on odontoblast like cells, induced by Lactobacillus acidophilus and propolis extract stimulation. Conclusion: Propolis extract stimulations lower the TLR2 and TNFα expression on odontoblast like cells, induced by inactive Lactobacillus acidophilus

STIMULASI EKSTRAK PROPOLIS PADA ODONTOBLAST LIKE CELLS YANG DIINDUKSI LACTOBACILLUS ACIDOPHILUS INAKTIF TERHADAP EKSPRESI TLR2 DAN TNFα