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Abstrak : Psoriasis merupakan penyakit inflamasi kulit kronis yang dipengaruhi oleh multifaktor dengan prevalensi di dunia berkisar 2-3%. TGF-β 1 adalah faktor pertumbuhan yang mempunyai polimorfisme pada gennya. Polimorfisme gen TGF-β 1 berperan dalam patogenesis psoriasis. Metode: Penelitian ini merupakan penelitian deskriptif dengan teknik simple random sampling. Subyek penelitian ini adalah bahan baku tersimpan (BBT) berupa hasil isolasis DNA penderita psoriasis sebanyak 62 sampel yang terdiri dari 33 perempuan dan 29 laki-laki. Penelitian ini bertujuan untuk melihat distribusi frekuensi polimorfisme gen TGF-β 1 (T869C) pada penderita psoriasis. Polimorfisme gen TGF-β 1 (T869C) dianalisa dengan PCR-based restricted fragment length polymorphism (PCR-RFLP). Hasil: Distribusi frekuensi polimorfisme gen TGF-β 1 (T869C) pada penderita psoriasis paling banyak terdapat pada genotip TC (50,0%) dibandingkan dengan genotip TT (6,5%) dan CC (43,5%). Kesimpulan: varian TC merupakan varian terbanyak dari polimorfisme gen TGF-β 1 (T869C) pada penderita psoriasis di kota Medan. Kata kunci : TGF-β 1 , Psoriasis, Polimorfisme Gen. Distribution of Beta-1 Transforming Growth Factor Gene Polymorphism (T869C) in Psoriasis Patients in Medan City, North Sumatra Abstract : Psoriasis is a chronic inflammatory skin disease that is influenced by multifactor with a prevalence in the world around 2-3%. TGF-β1 is a growth factor that has polymorphism in its genes. The TGF-β1 gene polymorphism plays a role in the pathogenesis of psoriasis. Method: This research is a descriptive study with simple random sampling technique. The subject of this research is the stored raw material (BBT) of DNA isolation from 62 psoriasis sufferers consisting of 33 women and 29 men. This study aims to look at the frequency distribution of the TGF-β1 gene polymorphism (T869C) in patients with psoriasis. The TGF-β1 gene polymorphism (T869C) was analyzed by PCR-based restricted fragment length polymorphism (PCR-RFLP). Results: Frequency distribution of TGF-β1 (T869C) gene polymorphism in psoriasis patients was most prevalent in TC genotype (50.0%) compared to TT genotype (6.5%) and CC (43.5%). Conclusion: TC variant is the most variant of TGF-β1 (T869C) gene polymorphism in psoriasis sufferers in Medan city. Keywords: TGF-β1, Psoriasis, Gen Polymorphism.

Distribution of Beta-1 Transforming Growth Factor Gene Polymorphism (T869C) in Psoriasis Patients in Medan, North Sumatra