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NEAE (Nonepisodic angioedema associated with eosinophilia) is a relatively common allergic disease in East Asia in which angioedema is confined to the extremities, is transient and does not recur, and is not accompanied by fever or highly elevated IgM. In this study, we report a case of NEAE disease with edema of the extremities in a young female who was able to be followed up with serum cytokines and serum immunoglobulins as biomarkers. Our results suggest that not only clinical findings but also serum biomarkers are useful in monitoring the disease status of NEAE.

A case report of nonepisodic angioedema with eosinophilia in a young Japanese female followed up with serum cytokines and immunoglobulins