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Vitamin D deficiency has been related to increased risk of myocardial infarction, stroke. Type 1 DM patients have a higher risk of atherosclerosis, which is the leading cause of death in most patients, and IFN-γ is a pro inflammatory cytokine, and type 1 DM is a chronic inflammation. In our study, we try to detect the premature atherosclerosis in adolescents with type 1 DM who have vitamin D deficiency through inflammatory IFN-γ. The study is a case control with 31 diabetic children aged 6 to 18 years as a case group, and control group 35 healthy children aged 10-18 years. We analysis the vitamin D, IFNand ,HbA1c, and using Doppler US for cIMT of common carotid artery(CCA), and flow mediated dilation index(FMD%) of the brachial artery. And analysis the data through SPSS version16.0. Type 1 DM group have higher levels of IFN-γ (p-0.005) and cIMT (p-0.01.) and both were significant, while the correlation effect of vitamin D deficiency and IFN-γ on both cIMT and FMD% were (p-0.294) and (p-0.270) (p0.794)and (p-0.894) respectively and both insignificant, and correlation effect of HbA1c on cIMT was significant with (p-0.002), and correlation effect of HbA1c on FMD% was insignificant with (p-0.222). We concluded that there is significantly higher of IFN-γ in type 1 DM, also a significant correlation effect of HbA1c on cIMT, and no relationship between vitamin D deficiency and premature atherosclerosis in an adolescents with type 1 DM through inflammatory IFN-γ.

Relationship between vitamin D deficiency and premature atherosclerosis in an adolescents with type 1 DM through inflammatory IFN-γ