English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Article history Received: 20 December 2019 Accepted: 29 December 2019 Published: 31 December 2019 Polymerase-tautomeric model for untargeted delayed base substitution mutations is proposed. Structural analysis of bases insertion showed that any canonical bases may be inserted opposite rare tautomeric forms of thymine T3*, adenines A2* and A4* so that between them hydrogen bonds are formed. Canonical adenine and cytosine can be incorporated opposite canonical thymine only. Canonical thymine and guanine can be incorporated opposite canonical adenine only. If in the synthesis of DNA containing rare tautomeric forms of thymine T3*, adenines A2* and A4*, involved DNA polymerases with relatively high fidelity of synthesis, mutations not appear. However, if further DNA synthesis will involve DNA polymerases having a low fidelity of synthesis, there may be base substitution mutations. It was shown that the conclusion made in the Tomasetti and Vogelstein cancer risk model that the formation of about 67% of all mutations was not caused by exposure to any mutagens is erroneous.

journal of oncology research

Polymerase-tautomeric Model for Untargeted Delayed Base Substitution Mutations Formation during Error-prone and SOS Replication of Double-stranded DNA Containing Thymine and Adenine in Some Rare Tautomeric Forms