Open AccessEffect of Vitamin E as α-Tocopherol Acetate on Mercuric Chloride-Induced Chronic Oxidoreductive Stress and Nephrotoxicity in Rats
Author(s) -
Ajwad Awad Muhammad Assumaidaee,
Nathera M. Ali,
Ammar A. Fadhil
Publication year - 2019
Publication title -
the iraqi journal of veterinary medicine
Language(s) - English
Resource type - Journals
eISSN - 2410-7409
pISSN - 1609-5693
DOI - 10.30539/iraqijvm.v43i2.538
Subject(s) - malondialdehyde , oxidative stress , vitamin e , chemistry , nephrotoxicity , antioxidant , superoxide dismutase , glutathione peroxidase , glutathione , toxicity , pharmacology , vitamin c , kidney , biochemistry , endocrinology , medicine , enzyme , organic chemistry
Impact of vitamin E against mercuric chloride induced nephrotoxicity in Wister albino rats was studied. Feeding rats with contaminated diet and water with HgCl2 at a non-lethal dose of (0.20 mg HgCl2/kg food or water) every other day for 42 days resulted in significant increase in the serum malonaldehyde (MDA), a biomarker of lipid peroxidation and significant decrease in the reduced glutathione concentration and glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) enzymes activities as compared to the normal group. Simultaneous co-administration of vitamin E (as α-tocopherol acetate) 100 mg/kg BW/+p.o, every other day for 42 days along with mercuric chloride produced a pronounced cardinal nephroprotective effect against the mercuric chloride induced nephrotoxicity by restoring the normal levels of the estimated biochemical antioxidant parameters. In conclusion, serum biochemical and kidney histopathological findings of the current study highlight the beneficial antioxidoreductive stress ameliorative effects of vitamin E against HgCl2-induced nephrotoxicity in rats.
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