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This study aimed to produce silver nanoparticles using aqueous extract of Nigella sativa, also to investigate the effects of green synthesized Nigella sativa seeds silver nanoparticles on dyslipidemia and DNA fragmentation in hydrogen peroxide-exposed rats. The produced Nigella sativa seeds silver nanoparticles were characterized through Ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction (XRD) style, and Scanning Electron microscope, and the morphology and size of these synthesized nanoparticles were investigated. Forty adults male rats were randomly and equally divided into five groups, which had been inspected daily for two months as followings: G1 group (Control), G2 group received tap water containing 1% H2O2, animals in G3 and G4 groups were injected IP with the nanoparticles in a dose of 25 and 50 mg/kg BW, respectively, and also received ordinary tap water containing 1% H2O2 , and in G5 group, the animals were injected IP with Nigella sativa seeds extract in 50 mg/kg BW and received ordinary tap water containing 1% H2O2. Blood samples were collected after one and two months of the experiment from each animal for DNA fragmentation measurements and serum lipid estimation. The results reported a case of dyslipidemia, as well significant elevation in DNA damage in G4 and G2 groups. The results also confirmed the hypolipidemic and cytoprotective effect of Nigella sativa seeds extract (G5 group) and silver nanoparticles, and group G3 clarified the correction between dyslipidemia, and the significant alleviation in DNA damage. In conclusion, the current study shows the effects of high doses of Nigella sativa seeds silver nanoparticles, and documents the ameliorative effect of these seeds extract and their silver nanoparticles on lipid profile and DNA damage.

the iraqi journal of veterinary medicine/al-maǧallaẗ al-ṭibbiyyaẗ al-bayṭariyyaẗ al-’irāqiyyaẗ

Synthesis, Characterization of Silver Nanoparticles Using Nigella sativa Seeds and Study Their Effects on the Serum Lipid Profile and DNA Damage on the Rats’ Blood Treated with Hydrogen Peroxide