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Nowadays the resistance of microorganisms to antibacterial drugs is a global problem of healthcare. Due to the increase in cases of diseases caused by resistant bacteria, the severity of their treatment, frequent mortality, the World Health Organization recommends the development of new antimicrobial agents against multidrug-resistant pathogens. The most dangerous are ESKAPE microorganisms, which are characterized by high antimicrobial resistance. These include the following microorganisms: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. It is known that derivatives and metabolic products of microorganisms are successfully used to combat etiologically significant pathogens of diseases separately and together with antibacterial drugs. Scientists have shown that the combined antimicrobial use of nisin (product of metabolism of Streptococcus lactis) with penicillin / chloramphenicol is effective against Staphylococcus aureus SA113 and Staphylococcus pseudintermedius DSM21284. The combination of vancomycin / ciprofloxacin against resistant and methicillin-susceptible strains of S. aureus, with polymyxin is effective in inhibiting pseudomonas growth.

MINIMUM INHIBITORY AND BACTERICIDAL CONCENTRATIONS OF ANTIBACTERIAL DRUGS SEPARATELY AND TOGETHER WITH METABOLIC COMPLEXES OF LACTOBACILLUS RHAMNOSUS GG AND SACCHAROMYCES BOULARDII