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In this study, the therapeutic effect of a novel human parathyroid hormone analogs nasal drops on ovariectomized rats was evaluated. Thirty-two of 40 3-month-old female Sprague-Dawley rats were ovariectomized and 8 received sham operation. Thirteen weeks later, ovariectomized rats were randomly and averagely divided into 4 groups: low dose, middle dose and high dose group (31.25, 125, 500 μg/rat respectively) and vehiculum group (0.5 mL/rat). Each group was administered to the nasal drops. Another 8 sham-operated rats were treated in the same way as those of vehiculum group. All rats were administered daily. After 16 weeks of continuous administration, the osteogenic ability was compared between rats in each group. The results indicated that compared with vehiculum group, significant increments in the dry weights of femur, trabecular area and trabecular width were shown in the groups treated with middle dose and high dose hPTH'. The results showed dose dependence. It is concluded that hPTH' nasal drop is effective in stimulating bone formation and improving skeletal microarchitecture and potentially an effective therapeutical agent on osteoporosis.

Therapeutic Effect of a Novel Human Parathyroid Hormone Analog Nasal Drops on Osteoporosis Rats