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Objective: To investigate the effects of external application of Ginkgo Semen (GS) paste on tinea corporis model of rat. Methods: Tinea corporis rats model were established by vaccination trichophyton mentagrophytes in skin wound. Observe the effects of the high, low dose of GS alcohol paste group and the high, low of GS water paste on symptoms integral before and after treatment, the skin lesions inverse culture and the local tissue morphology in tinea corporis rats model. Results: Tinea ulcer model rats successfully. Compared with the model group, the high, low dose of GS alcohol paste group and the high, low GS water paste could significantly or remarkably reduce the symptoms integral, remarkably increase the skin inverse culture turn rate and improve the pathological changes. Conclusion: The external application of GS paste has remarkable curative effect on tinea corporis rats model. KEYWORD: Ginkgo Semen(GS) paste; External application; Tinea corporis model International Conference on Social Science, Education Management and Sports Education (SSEMSE 2015) © 2015. The authors Published by Atlantis Press 1274 with strain 10 ·ml of bacteria suspension. 3.2 Build the tinea corporis model of rat and observation index [4] Before one day of the experiment would each rat right back hair removed, which covered an area of 9 cm 2 .Then shed coated hair removal liquid lightly, after 8min with warm water to wash hair removal liquid residue. The rats after depilated were randomly selected 10 rats as the control group, the remained 70 rats in the shed at the skin with a scalpel scratch until blood oozing for the degree. Then take the bacteria culture, smeared on the wound with a razor blade, wrapped with gauze and then tape wrapped to prevent break. Bacterial contamination observed daily and repeat until the 9th day lesions appeared. After contaminated successfully, according to the literature method severity score [5]. (No lesions were "0", a few erythematous papules or lesions tend to heal, grow new hair were "1", an island like erythema fusion or scattered around and red were "2", a comprehensive expansion of a large number of erythema, scales and thick skin were"3", accompanied by bleeding very lesions were "4"). According to the lesion score and male and female the rats were randomly principle divided into 7 groups, Topical respectively high and low dose of GS alcohol paste (0.60g · ml, 0.30g·ml), high and low dose of GS water paste (0.60g·ml, 0.30g·ml), Xianyaogao (thickness of 2mm), the control group and the model group smeared 0.9% sodium chloride injection of 1.0ml, the excipient matrix group paste coated (thickness of 2mm). The rats were used two layers of gauze dressed liquid adsorption corresponding parts of the back sides of tinea, treated and covered with plastic wrap, after administration of 6h, used the 0.9% sodium Chloride Injection to cleaned the partial. Administered once a day, medicated for 12 days continuously. Rats were observed healing lesions daily, every four days reference standard severity scores were scored and recorded, 12th day after administrated of 6h drug and saline washed. The rats were killed, taking parts of the skin lesions, lesions at each per rat take 4 skin, which a skin wound fixed in 10% formalin solution, skin inflammation was observed under paraffin-embedded sections, HE stained and microscopied. The remained three into 70% soaked ethanol for 2-3 minutes, bacteria was killed, after washed with sterile saline in a sterile room inoculated in potato dextrose agar medium and marked and then put the dish in the incubator 37 °C culture, removed after 1 week, required to observe the growth of Trichophyton ringworm. 3.3 Methods Statistical Analysis Data analysis used SPSS 17.0 for windows for statistical treatment. measurement data represented by mean±variance ( x±s), group comparison used analysis of variance; ranked data used Ridit test.

Effects of External Application of Ginkgo Semen Paste on Tinea Corporis Model of Rat