English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

To investigate the effect of total anthraquinone of Polygonum cuspidatum (TAPC) in diabete rats which were established by streptozotocin. Method: The diabete rat model was established by injected with streptozotocin, and then randomized into 5 groups. Which were fed with high dosage TAPC group, medium dosage TAPC group, low dosage TAPC group (400mgkg -1 ,200mgkg -1 ,100mgkg -1 ), metformin group (208 mgkg −1 ) and model group. Control group was set up with healthy normal rats. All the rats were administrated once a day for 30 days. Blood glucose (BG) in the limosis were measured on the 20, 30 day and then rats were sacrificed. The levels of insulin, insulin antibody, leptin, C-peptide in orbital blood were measured. Results: Diabetic model rats successfully. Compared with model group, The high dosage TAPC group can significantly reduce the level of blood suga on 30 day(P<0.01), Can significantly reduce the level of blood suga on 20 day (P<0.05); The medium dosage TAPC group significantly reduce the level of blood suga on 20, 30 day (P<0.01); The medium and low dosage TAPC group significantly increased the level of insulin (P<0.01); Each dosage TAPC group can significantly reduce the level of C-peptide (P<0.01). Conclusion: TAPC has good hypoglycemic effect on the diabete rats established by injection of streptozotocin KEYWORD: Total anthraquinone of Polygonum cuspidatum (TAPC); Diabete model; Streptozotocin; Insulin antibody; Leptin; C-peptide.

Effects of Total Anthraquinones of Polygonum Cuspidatum on the Levels of Insulin, Leptin and C-Peptide in Serum in Diabete Rat Model