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The important intermediate, (R)-methyl 5-hydroxy-3-oxoheptanoate, of study towards to total synthesis of (+)- Clavosolide A (1) was described, which was commenced from commercially available D-phenylalanine.

Synthetic Study towards (+)-Clavosolide A: Synthesis of the Intermediate of (R)-methyl 5-hydroxy-3-oxoheptanoate