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R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazolidine-3-carboxylate, an key intermediate of Biotin which is a water-soluble vitamin involved in an essential part of the metabolic cyle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and α-amino acids, was synthesized from L-cystine in overall yield 41% through six steps, which included esterification, Boc protection, acetonization, reduction, Corey-Fuchs reaction.

Study on Synthesis of (R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazo lidine-3-carboxylate