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Benzothiazole derivative (BD): (N-(3-(benzothiazol- 2-yl) phenyl)-1H-pyrazole-3-carboxamide) was tested for excretion of total sterols of high-fat diet fed C57BL/6J mice in view of lipid metabolism. The results showed that BD as supplementation of high-fat diet significantly improved the output of cholesterol in comparison to HF alone. Relevant mRNA expressions of HMG-CoA-R, SREBP-2, LDL-R, CYP7A1 and PPARα were significantly altered in liver. These results suggest that BD could promote the excretion of total sterols and play a beneficial role in lipids metabolism for a high-fat fed mice.

Benzothiazole Derivative Accelerates Excretion of Total Sterols in Long-Term High Fat Fed C57BL/6J Mice