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More and more useful drug controlled release profiles have been reported in literature for potential applications of “efficacious, safe and convenient” drug delivery [1–9]. These profiles include immediate release, pulsatile release, delayed release, sustained release, zero-order kinetic release, dual-stage release, and multiple-phase release in terms of the drug release rate and initiating time [10–17]. Among these profiles, dual-stage release is composed of a first rapid release for quickly eliminating the uncomfortable symptoms (such as ache, fever and depression) and a later sustained release for a long time period to considerably reduce the administration times [18–21]. This controlled release profile holds the advantages of both pulsatile release and sustained release, and thus has a high patient compliance.

Dual-stage Release of Ketoprofen from Electrosprayed Core–Shell Hybrid Polyvinyl Pyrrolidone/Ethyl Cellulose Nanoparticles