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The content and evolution of academic research on regional innovation systems from 1997 to 2018 are analyzed. The growing importance and relevance of the topic, in both practical and academic terms, are emphasized. Different approaches to define RIS and its components are summarized. Special attention is paid to research on models of regional innovation systems. Recommendations for future research are presented. Keywords—spatial economy; regional innovation system; regional innovation subsystem; regional innovation policy; regional innovation collaboration; models of the regional innovation systems; regional systems of innovation

Regional Innovation Systems: Content and Evolution of Academic Research