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Novel nitro-benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of them, 5-nitro and 8-nitro bearing ones displayed significant activity in IC50 values of 4.6 and 13.45μM. Their docking behaviors were also studied. KEYWORD: Nitro compound; benzothiadiazine 1,1-dioxide; aldose reductase inhibitor International Conference on Industrial Technology and Management Science (ITMS 2015) © 2015. The authors Published by Atlantis Press 1077 2 RESULTS AND DISCUSSION

Novel Nitro Derivatives of Benzothiadiazine 1,1-Dioxide as Aldose Reductase Inhibitors