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This report is about using the similarity of drugs or genes to predict possible interaction between drug and gene. I use SVM and NRWRH in different condition. And then analyze the advantage and disadvantage of them, respective. I also propose some factors which can impact those results. KEYWORD: SVM; NRWRH; Drug-gene; Interaction Prediction International Conference on Industrial Technology and Management Science (ITMS 2015) © 2015. The authors Published by Atlantis Press 1027 into a heterogeneous network by known drug-target interactions; secondly, the initial probability of random walk is determined to make random walk start at the given drug nodes and seed target nodes simultaneously; then random walk on the heterogeneous network is implemented; finally the most probable targets are selected according to the stable probability of the walk. Fig.2 Transform a non-seperable question to a seperable question by dimension raising

Advantages and Disadvantages of SVM and NRWRH in Drug-gene Interaction Prediction