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Dengue Hemorrhagic Fever (DHF) is a major problem in Indonesia. In 2016, Incidence Rate (IR) = 77.96/100.000; Case Fatality Rate (CFR) = 0.79%. Semarang City, the Capital of Central Java Province, is an endemic area of DHF. Gunungpati is a subdistrict that has a high incidence of DHF. Some health workers sell abate (temephos) without notifying the appropriate dosage. Long-term use of larvacide and inacurate dosage may lead to resistance. This study aimed to determine the resistance status of Aedes aegypti larvae to temephos in Gunungpati sub-district. The population study was all of Ae. aegypti larvae in Gunungpati sub-district and the sample was Ae. aegypti larvae trapped by ovitrap and reared by researcher to obtain the first generation (F1). F1 larvae would be randomly exposed to temephos, with doses according to the WHO guidelines. We counted larval death after 24 hours of exposure by larval resistance indicator. This was true experiment with randomized pretest-posttest design with control group. The results showed that Ae. aegypti larvae in Gunungpati sub-district were tolerant to temephos, because the average of larvae mortality were 81-95% in temephos exposure with WHO-recommended dose. Keywords— resistance, Aedes aegypti, temephos.

Resistance Status of Aedes Aegepty Larvae Against Temephos in Gunungpati Subdistrict, Semarang