English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This paper is the part of a large-scale project concerning studying of bovine leukemia virus biological diversity and of the influence of BLV structural characteristics on virulence and hematolytic blood parameters of infected animals in Western Siberia. This part is devoted to the study of the influence of haplotypes which are determined by mutations in gag gene on several blood parameters and on the number of viral particles per 1000 healthy cells. Emphasis is made on the importance of bioinformatics analysis for processing large data arrays during the multivariant analysis of BLV carriers’ parameters. It was established that about 3⁄4 of infected animals were infected with II haplotype virus, whereas the remaining part was infected with BLV of I haplotype. The number of leukocytes, including lymphocytes, erythrocytes, and platelets in the blood of animals infected with II haplotype virus, was generally higher than that of the carriers of I haplotype. Viral load in carriers of II haplotype was 800-1000 viral particles per 1000 healthy cells, whereas the number of viral particles per 1000 healthy cells in the blood of individuals with I haplotype ranged from 600 to 900. It is worth noting that among carriers of I haplotype there were no animals with clinical signs of leukemia, and viral load in healthy animals exceeded that in suspicious individuals. In general, it was shown that gag gene, along with LTR region, is a rather significant factor in maintaining of “viral load – immune response” correlation. Keywords— cattle, BLV, leukemia, gag gene, PCR analysis, omix technologies.

Application of omix technologies in studying of BLV biological diversity by gag gene