English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Conjugation of immunogenic fraction separated from microbial cells of BCG strain with stimulating component proved to be a promising direction in the creation of antituberculosis drugs. One of such components is KIM-M2, a complex of thermostable soluble antigens extracted from microbial cells of BCG strain incubated with formalin and conjugated with polyvinyl pyrrolidone and polyethyleneglycol. To study the impact of KIM-M2 on the morphology of lymph nodes, spleen, lungs and liver of guinea pigs, the animals of group 1 (control, n = 5) were injected subcutaneously with a virulent culture of M. bovis strain 8 at a dose of 0.001 mg/ml. Animals of group 2 (n = 5 subjects) were injected subcutaneously with KIM-M2 at a dose of 0.5 mg/ml of protein, then 30 days later they were injected with a virulent culture of M. bovis strain 8, subcutaneously at a dose of 0.001 mg/ml. Animals of group 3 (n = 5 subjects) were injected subcutaneously with a virulent culture of M. bovis strain 8 at a dose of 0.001 mg/ml, 14 days later they were injected with KIM-M2 at a dose of 0.5 mg/ml of protein. Histomorphologic changes in animals of group 1 can be considered as morphological equivalent of immune suppression reaction. At the same time, the animals from group 2 and especially from experimental group 3 showed an increase of immunogenesis that can be proved by a profound proliferation of lymphocytes

Influence of Anti-tuberculosis Drug KIM-M2 on Morphology of Lymph Nodes, Spleen, Liver and Lungs of Guinea Pigs Infected with M. bovis