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Cipangopaludina chinensis which is a kind of benthic invertebrates was taken as experimental invertebrate. In the condition of the Roxithromycin, the activity of APND and GST abstracted from the liver and kidney tissues of Cipangopaludina chinensis to investigate the effect of Roxithromycin on the biochemical indicator of Cipangopaludina chinensis have been tested. The experimental results showed that there were affections on the activity of snail liver and kidney in Cipangopaludina chinensis with Roxithromycin, and the overall trend was promenting at the beginning then suppressing at the end, but the differences of the influence caused by different concentrations of Roxithromycin erythromycin was not obvious. In addition, it appeared from the survival condition of control group and experimental group that Roxithromycin as a kind of antibiotic, has no lethal effect on Cipangopaludina chinensis. But the concentration which is more than 250 times, 500 times and 750 times of the environment used in this experiment had significant influence on the activity of the APND and GST. If the concentration is higher, the influence may be more serious and it is possible to be death.

The effects of Roxithromycin on the Activity of APND and GST in Cipangopaludina Chinensis