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Under the background of "general entrepreneurship" and "public innovation", the paper is based on national development strategy driven by innovation and deep understanding of applied innovative entrepreneurial talents. The main emphasis of the paper is placed on the school-running orientation of application and the target of talent-cultivating. The paper analyzes series of theoretical and practical problems of the top-level design for personnel training, the teacher troop, integration with production services, and so on. It takes practice system construction as the core and incubation system construction as the foothold. The paper is to construct practical "1 + 5 + 1" cultivation system of innovation and entrepreneurship supported by construction of security system. It is of significance to provide the replicable and scalable educational model of creative reform of education and teaching and mechanism of innovation entrepreneurship for application colleges and universities. It demonstrates the effective transitional breakthrough and development in application colleges and universities. Keywords—application colleges and universities, innovation and entrepreneurship, innovation and entrepreneurship education, practical education, system

The Construction and Practice of q1+5+1q Innovation and Entrepreneurship Practice Education System in Applied Universities