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Function loss of large skeletal muscle is an urgent problem in the clinic. Although the artificial microfluidic network encapsulated in thick tissue-engineered constructs has a great promise, it is still difficult to develop an efficient microfluidic design to fit the requirements of the bionic vascular network for tissue engineering application. In this study, a seriers of biomimetic principles was outlined and a vascular network for muscle tissue engineering was designed following these principles. CFD analysis indicated that the velocity error of fabricated model was controlled within 10% in the different pressures, the velocity curve of designed model and fabricated model are better matched when the inlet pressure is 6 mmHg. Therefore, the future work will focus on the in vitro tests with this inlet parameter to verificate and optimize the vascular networks and validating their ability to support myoblast for clinical use.

Design and Fabrication of Vascular Network for Muscle Tissue Engineering