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This study aimed to determine the potency of combination of medicinal plants, which is curcumin and vitamin E as an alternative herbal for breast cancer treatment using DMBA ((7,12Dimethylbenz(a)anthracene) induced rats (Rattus norvegicus) as animal model. The treatments were normal rats as negative control group (NCG), DMBA induced rats as breast cancer suffering rats or positive control group (PCG), and DMBA induced rats treated with combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day for 14 days as treated positive control group 1 (TPCG 1) and DMBA induced rats as breast cancer suffering rats or positive control group (PCG), and DMBA induced rats treated with combination of curcumin 48 mg per kg body weight per day and vitamin E 300 IU per head per day for 14 days as treated positive control group 2 (TPCG 2). Therapy of the DMBA induced rats was done per orally using combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day for 14 days. After the 14 days, euthanasia was done on the rats and blood samples were collected from each rat for laboratory analysis of estrogen and progesterone concentration using Enzyme Linked Immunosorbent Assay (ELISA) procedure. It was clearly shown that combination of curcumin 72 mg per kg body weight per day and vitamin E 200 IU per head per day has potential as an anti cancer therapy, as characterized by the decrease of blood estrogen concentration, the increase of blood progesterone concentration, and the disappearance of nodules in the breast tissues of cancer suffering animals.

Potency Combination of Curcumin (Curcuma longa Linn.) and Vitamin E Toward Estrogen and Progesterone Profile on Rat (Ratttus norvegicus) Mammary Cancer Model