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Hypercholesterolemia is a major risk factor of cardiovascular disease. Hypercholesterolemia is a condition that the cholesterol levels in the body exceed the normal limits. The main factor that causes high cholesterol levels in the body is a high-cholesterol diet. The provision of highcholesterol diet may improve cholesterol levels, especially LDL cholesterol. This condition leads to LDL oxidation, furthermore generation of free radicals or ROS that causing lipid peroxidation. Products of lipid peroxidation by ROS compound is an MDA compound. Countermeasures against ROS required antioxidant compounds. Probiotics that contain lactic acid bacteria can increase antioxidant. Probiotic of Lactobacillus casei Shirota strain contained of lactic acid bacteria that can increase the antioxidant content and decrease cholesterol levels. The aim of this study was to determine the probiotic of Lactobacillus casei Shirota strain potential to MDA levels of rats blood serum and histopathology of rats aortic tissue that fed with high-cholesterol diet. This study used male white rats (Rattus norvegicus) Wistar strain were divided into negative and positive group and therapy groups doses of Lactobacillus casei Shirota strain is: 0.5, 1 and 1.5 mL/rat/day, that each group contained 5 rats.. The positive control group and therapy group administrated high-cholesterol diet for 21 days. The results showed that probiotic of Lactobacillus casei Shirota strain decreased the MDA levels of blood serum up to 60.15% at dose of 1.5 mL/rat/day and can improve the histopathology of aortic tissue on high-cholesterol diet rats. This result demonstrated that Lactobacillus casei Shirota strain probiotic had potentially as treatment of hypercholesterolemia.

Potential of Lactobacillus casei Shirota Strain as Probiotic toward MDA Levels and Histopathology of Aortic Tissues in Rat with High Cholesterol Diet