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Oxidative stress can be induced by strenuous exercise either in human or in animal, it can damages erythrocyte during and post-exercise. Furthermore, maximum exercise also affecting leukocyte level. In another hand that vitamin E as an agent of antioxidant might be potentially can be a protector for damage erythrocyte and leukocyte caused by strenuous exercise. The purpose of this study was to investigate effects of vitamin E 0.2 mg and 0.4 mg on the change of erythrocyte and leukocyte levels in male rats (Mus musculus) due to strenuous exercise for twenty eight days. Randomized post-test controlled group design was used in this study. Twenty male rats (2-4 months old) were divided into four groups: 1) Control Group (G1); 2) Strenuous Exercise Group (G2); 3) Strenuous Exercise Group + 0.2 mg of vitamin E (G3); 4) Strenuous Exercise Group + 0.4 mg of vitamin E (G4). Strenuous exercise had given every day for 28 days. One-way ANOVA and Post Hoc Tukey was performed to analyze the data. The results showed that the erythrocyte level of strenuous exercise group (G2) was lowest compared to G1, G3, and G4 (P < .05) as well as the leukocyte level as the P-value < .05. The conclusion is the treatment of vitamin E is able to prevent the damage of erythrocyte and to maintain the steady level of leukocyte due to strenuous.

Vitamin E Changes Erythrocyte and Leukocyte Levels in Male Rats (Mus Musculus) Due to Strenuous Exercise