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Wound is defined as a damage of the normal anatomical structure and function of tissues. Aloe verais one of potential herbal on wound healing. The aim of this study is to explore the effect of topical Aloe vera on skin wound healing in Sprague Dawley rats. Thirty six male Sprague Dawley rats 150-200 grams were divided into four groups. All groups were anaesthetised, shaved, and exposed two round full-thickness punch biopsy on the back. Group I as control group; group II treated with topical application of Aloe vera cream 1%; group III treated with topical application of Aloe vera cream 2%; and group IV treated with topical application of madecassol®. The treatments were given once a day, for 15 days. Macroscopic and microscopic examination were observed at 5, 10 and 15 days post skin biopsy. Skin specimens were prepared for histopatological study using Hematoxillin and Eosin (HE) and immunohistochemistry (IHC) staining. HE were used to analysed epidermal thickness, leucocytes infiltration, fibroblast, and angiogenesis. IHC using antibody anti-CD4 + and CD8 + were used to analysed the expression of CD4 + and CD8 + lymphocytes. All the microscopical data collection were performed by ImageJ software, and then all data were analysed by Statistical Package for the Social Sciences 16(SPSS.16). Result of this research shows that topical application of Aloe vera cream 1% and 2% significantly reduced the percentage of wound, leucocytes infiltration, angiogenesis, expression of CD8 + lymphocytes. However, epidermal thickness and the expression of CD4 + lymphocytes increased (p ≤ 0,05). There were no significant different in the number of fibroblast in all groups. Topical application of Aloe vera 1% and 2% have wound healing potential via its ability to increase the ratio of CD4 + /CD8 + lymphocytes in the wound area.

Effects of Aloe vera Cream On Skin Wound Healing In Sprague Dawley Rats: The Role of CD4+ And CD8+ Lymphocytes