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A novel and efficient molecular imprinted polymers (MIPs) electrochemical sensor based on metal coordination technology was prepared by electro-polymerization, which was applied as a molecular recognition element to modify glassy carbon electrode (GCE) to construct an electrochemical sensor (MIPs/IDA/GR/GCE) for sensitive detection of lysozyme (Lyz). The prepared MIPs/IDA/GR/GCE showed a fast rebinding dynamics, which was successfully applied to Lyz detection with a wide linear range from 1.0 ×10 -11 to 1.0 × 10 -5 g/L (R=0.998) and a detection limit of 2.3 × 10 -12 g/L. Moreover, the fabricated sensor possessed a good selectivity and sensitivity, providing a promising tool for immunoassays and clinical applications. Keywords-electrochemical sensor; metal coordinate technology; lysozyme; electro-polymerization

Surface molecular imprinted electrochemical sensor for lysozyme based on metal coordinate technology