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The purpose of the work is to study the immunomodulating activity of L-carnitine in junior athletes during the training period. Materials and methods. 20 junior athletes (masters of sports and candidates for masters of sports in swimming) aged 14-18 years participated in the study. Athletes were divided into 2 groups of 10 people each. Athletes of the main group received L-carnitine (600 mg per day) for 4 weeks in addition to the basic diet. Athletes of the control group received only basic diet without sports nutrition. Examination of athletes was performed at the beginning and after 4 weeks of the observation period. Results. As a result of a comprehensive survey of junior athletes, the positive effect of L-carnitine intake on erythrocyte hemoglobin content (30.2 ± 0.4 pg vs 28.3 ± 0.3 pg at the beginning) was observed. The relative content of basophilic leukocytes in athletes of the main group statistically significantly decreased by the end of the observation period from 0.64 ± 0.05% to 0.45 ± 0.04%, which indicated an increase in the body's resistance to allergic reactions. The biomarkers of the immunotropic effect of L-carnitine are a decrease in the expression of the apoptotic marker CD95/Fas on peripheral blood lymphocytes and suppression of the production of proinflammatory cytokines synthesized by Th1 lymphocytes with switching the response to humoral immunity. An evidence base for the effectiveness of the use of L-carnitine in sports nutrition for restoring immune dysfunction and adaptive potential of junior athletes has been provided.

Immunological aspects of the use of L-carnitine in sports nutrition