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Neutrophil extracellular traps (NETs) are destroyed neutrophils combined with DNA, proteins, and enzymes; they are the destruction mechanisms of a cell attacked by pathogens. Currently its pathophysiological contribution to the neoplastic process remains controversial. The aim is to determine the number of NETs in the blood of women with cervical cells malignization. The research covered 21 cases – 7 women with cervical premalignancies (I group) and 14 women with cervical cancer of stages 0-III (II group). The average age of patients was 38±8.26. The control group was formed of volunteers without cervical pathologies (n=10). Blood serum was used as the material for the research. Neutrophils, monocytes, and NETs were counted in Feulgen stained blood smears by the optical microscope. The count was performed per 100 cells. In addition, we performed retrospective analysis of some blood parameters of the examined individuals. NETs were not found in the blood of healthy women and women with premalignancies. NETs were observed in the blood of 70% of patients with cervical cancer. The maximum number was found in the blood of patients with stage IIb cancer. Leukocytosis was registered in the blood of the patients diagnosed with cervical cancer due to neutrophilia and lymphopenia. The discovered changes increased as the neoplastic process aggravated. The results of the study and literature data point to the existing changes in blood neutrophils of the patients with cervical cancer and NETs participation in cervical carcinogenesis which requires further research.

The Research of Neutrophil Extracellular Traps in the Blood of Women with Malignization of Cervical Epithelium