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The present work studies the polymorphic variants of XRCC1 (rs1799782) and RAD51B (rs10483813) genes, which are associated with the risk in developing a number of oncology diseases, particularly it relates to women with breast cancer, the place as location of their living we consider the Chechen Republic. A reliably significant risk for breast cancer development was detected, if 470T> C gene XRCC1 polymorphism among women (p = 0.04) is presented, which indicates the mutation involvement in malignancy pathogenesis. The RAD51 gene family plays the critical roles in the extensive genetic instability caused by the loss of their activity. The missense-variant A> G of RAD51B was identified in two cases among the patients (5.8 %) and two healthy women (2.7 %). The analysis towards the correlation of this mutation with malignant transformation of breast cells showed the significance of the minor G allele in odds ratio (OR = 2.04 with 95 % CI = 0.29– 14.51). However, the differences did not reach the statistical meaning (p> 0.621).

Polymorphic Variants of Genes RAD51B and XRCC1 Influence on Breast Cancer Development