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Natural Science learning in the 21st century is closely related to the scaling of scientific skills. Students practical skills is one of scientific skills which must be mastered. Applying practical skills in the laboratory need an ability to scientific safety. This research was aimed to produce the students work sheet based on Laboratory InvestigationScientific Safety that feasible and effective to improve the student’s practical skills of Secondary School. This research and development (R & D) used Borg & Gall model with modification of eight steps; (1) preliminary study, (2) planning, (3) product development, (4) limited trial, (5) product revision, (6) field test, (7) product revision final product improvement) and, (8) limited dissemination. The data were collected by non-test techniques which included using product validation instrument, student questionnaire to response work sheet, practical skills observation sheet. Field trials were conducted using Pre-test-Post-test control group design with 35 subjects in the experimental and control classes. The data were analyzed using normality test, homogeneity test, and t test. The results were: (1) the students work sheet based on laboratory investigation scientific safety was considered good and proper by lecturer of media expert, material expert, science teacher, and colleague with mean value 89,5%, (2) the students practical skills improved to be 89.5 after using students work sheet. Practical skills improvement was evidenced by the acquisition of a t test significance value of 0.000 less than 0.05. Overall, it can be concluded that student’s product based on laboratory investigation scientific safety focused theme of human digestive system was feasible to be used in learning and effective to improve students’ practical skills of secondary school. Keywords—students work sheet, laboratory investigationscientific safety, practical skills

Work Sheet Development based on Laboratory Investigation-Scientific Safety to Improve Practical Skills on Secondary School