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Design and preparation of novel cross-linked polyvinyl alcohol extra permeable foam (cPVAEPF) dressings for negative pressure wound therapy(NPWT) was studied. A series of cross-linked polyvinyl alcohol extra permeable foam (cPVAEPF) dressings with different macroporosities in the range of 700 μm~920 μm were obtained. The dried cross-linked polyvinyl alcohol extra permeable foam (cPVAEPF) dressings showed good elongation rate in the range of ca.340%-404% and extra permeability in the range of 88~92%. The extra permeability and good elongation must be contributed from open cell structures. Characteristics of resulting cross-linked polyvinyl alcohol extra permeable foam (cPVAEPF) dressings could provide a powerful potential in the clinic application of negative pressure wound therapy(NPWT) and could enhance the range of clinic application of negative pressure wound therapy(NPWT). Keywords—PVA; Foam; Matrix

Design and Preparation of Novel Cross-linked Polyvinyl Alcohol Extra Permeable Foam Dressings for NPWT via a Combined Process of Super Clean Air foaming and Ultra Precision Machining