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There are various zebrafish models with cardiovascular defects which adequately mimic the impaired circulation and tissue perfusion of various human cardiovascular diseases. Zebrafish embryos/larvae are optically transparent, and the systemic blood circulation can be recorded by using a microscope with video imaging. We detected a series of circulatory defects in our caldesmon and glucose transport 1 knockdown zebrafish models, including arteriovenous (AV) shunting, collateral circulation, AV fusion, vessel bifurcation, reduced or depleted regional perfusion, sinus venous (SV) rupture, and more. The quick detection by simple video imaging of various pathological states of the blood circulation in the living zebrafish embryos/larvae is non-invasive and cost-effective. The method is suitable for large scale screening of altered blood circulation in various zebrafish models with impaired cardiovascular development. This is a powerful approach of live digital data communication in biomedical research and teaching.

A Powerful Approach of Live Digital Data Communication in Biomedical Research and Teaching:Detection of Various Impaired Vascular Perfusion in Zebrafish Knockdown Models by Video Imaging