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Background: The lozenge is one of the drugs to overcome a sore throat. This contained an active ingredient can be either a synthetic or herbal materials. Kaempferia galanga L is a medicinal plant that able to relieve cough and sore throat. So, its potential made be lozenges. Lozenges are compressed tablets which it must be using the binders on formulation. Objectives: This study was to investigate the effect of the binder on physical characteristic of squeezing rhizome of Kaempferia galanga lozenges using mannitol base. Evaluation was conducted using different kinds of binders (i.e., gelatin, hydroxypropylmethylcellulose (HPMC) 1290 cps and polyvinylpyrrolidone (PVP) K30 at 1%, 2%, and 3% concentrations. Methods: The squeezed rhizome of Kaempheria galanga L was dried using mannitol. The lozenges were prepared by a wet granulation method and compressed by a hydraulic press at 2-ton pressures. Lozenges had been evaluated, including hardness, fragility, and dissolves time of lozenges. Conclusion: Lozenges that contained Gelatine and PVP K30 in the concentration of 2% and 3%, both of them were as well at the range. While the lozenges that containd HPMC 1290 cps provides good results at the concentration of 3%. All parameters are dependent on the type, quality and concentration of a binder.

The Effects of Binder on the Physical Characteristic of Squeezed Rhizome of Kaempferia galanga L Lozenges