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MRI (Magnetic Resonance Imaging) of the myocardial perfusion plays an important role in the diagnosis of heart disease. However, it is important to alignment the time- series MRI perfusion images before to detect the grey level change at correspondence point. In this paper, a new alignment method is presented which combinesprincipal axes with block matching method. This is a two-step strategy from rough to fine alignment. At the first step, as to the rough alignment, principal axes method is used to obtain the approximate displacement and rotation angle. At the second step, block matching method with SAD principle is used to achieve fine alignment of ROI(region of interest), which divides the referred image and the image to be registered into several small pieces and uses full search method to find the matched parts. As a result, the accuracy and computational speed of the non-rigid alignment is improved significantly.

An Alignment Method for Time Sequence Myocardial Perfusion MR image