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A novel thiopyrano[4,3-d]pyrimidin derivative bearing a indole-hydrazone was synthesized and structure was confirmed by 1 H NMR and MS. Moreover, this compound was evaluated for its cytotoxicity against the H460 cell lines and inhibitory activity against mTOR kinase at a concentration of 10uM. The result indicated that this compound exhibited moderate activity against cancer cell line as well as mTOR kinase. At 10μM level, the inhibition rate of compound 1 against H460 cell lines and mTOR kinase was 39.6% and 47.0%.

Synthesis and Anticancer Activity Of One Novel Thiopyrano[4,3-D]Pyrimidine Derivative Bearing A Indole-hydrazone