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4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives is an important intermediate which inhibited tumor necrosis factor alpha and nitric oxide. In this work, a rapid and green synthetic method for compound (5) was established. The compound (5) was synthesized from the commercially available methyl 3-aminothiophene-2-carboxylate and formamidine acetate through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by 1 H NMR and MS. Furthermore, the total yield of the three steps was 43%.

Synthesis of 4- (Thieno [3, 2-d] pyrimidin-4-yl) Morpholine