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Multiple myeloma (MM) is a cancer of the immune system characterized by complex cellular and humoral immunodeficiency [1–3]. Patients with MM often have advanced age, increased comorbidity and are exposed to immunosuppressive drugs during therapy [4]. These factors contribute to markedly increased risk of infections, mainly pneumonia and sepsis [5–7]. These complications are responsible for a substantial part of early deaths in MM [7–9]. The incidence of bacterial infections and of blood cultures to detect them peaks in the first 6 months from diagnosis [10,11]. We have previously reported the results of a retrospective, single-center, realworld study conducted at Vejle Hospital (a primary and secondary referral center receiving approximately 30 newly diagnosed cases of MM per year), in which we reviewed the clinical course of 303 patients with MM who initiated treatment from 2006 to 2016 [12]. The aims of the present study were to describe, in a single-center cohort of patients with MM, the results of blood cultures, to determine their incidence and timing, and to assess their associations with baseline clinical characteristics and treatment-related factors. Moreover, we assessed the use of immunoglobulin replacement therapy (IGRT) in the study population.

The Incidence and Timing of Blood Cultures in Multiple Myeloma – Results from a Retrospective, Single Center, Real-World Study