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Cue-induced methamphetamine (METH) craving increases after prolonged forced abstinence from METH. In the present study, we employed male Sprague-Dawley rats to study METH reinstatement behavior induced by conditioned cue. We trained rats to self-administer METH under a fixed ratio 1 schedule for 10 sessions (4 hours/day), and then assessed METH induced by conditioned cues after 12 d extinction. Under both training and extinction conditions, the animals showed increased responding of nose poking on cue-induced during the period reinstatement. The results suggested that self-administration responding could be reinitiated by cue-induced from the drug environment in rats. The procedure used in this model may be useful for the study of the underlying mechanism of cue-induced reinstatement.

Reinstatement of Cue-induced Methamphetamine-seeking Behaviour